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Large-scale multi-residue methods for pesticides and their degradation products in food by advanced LC-MS

Fernández-Alba, A.R., García-Reyes, J.F.

Trends in Analytical Chemistry, Vol. 27, No. 11, 2008 (973-990)

Author Keywords

Degradation product; Food; Large-scale multi-residue method; Liquid chromatography; Mass spectrometry; Pesticide; Tandem mass spectrometry; Target analysis; Time-of-flight; Trace analysis


Pesticide testing in foodstuffs is a challenging application for mass spectrometry (MS), since it implies simultaneous trace analysis of hundreds of compounds belonging to a many classes, preferably undertaken in one fast run. The appearance and the use of new, more polar pesticides has prompted the use of liquid chromatography electrospray ionization MS (LC-ESI-MS) instead of gas chromatography. Currently, large-scale multi-residue methods (LSMRMs) (i.e. covering over 80 analytes) for pesticide analysis are developed using LC with tandem MS (LC-MS2) with triple quadrupole mass analyzers or LC with time-of-flight MS (LC-TOFMS).
The present article provides a review of the most significant MRMs for determining pesticide residues in foodstuffs. We discuss the main features of LC-MS2 and LC-TOF-MS instruments, including recently introduced advances in instrumentation. In addition, we describe the advantages and the pitfalls of these methods, together with examples of the application of LC-TOF-MS and
LC-MS2 to large-scale screening, identification and quantitation of pesticides in foodstuffs.


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Published 07-05-2009, 11:07:00


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